Fri Feb 27 2026

102 articles - From Friday Feb 20 2026 to Friday Feb 27 2026

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Clin Gastroenterol Hepatol
AGA Clinical Practice Update on Management of Gastric Polyps: Expert Review.

If the polyp is biopsied or resection is incomplete, follow-up endoscopy is advised within 3 months for high-grade dysplasia and 6 months for low-grade dysplasia. BPA 14: Endoscopic surveillance is advised in patients with gastric polyps when the histopathology of adjacent mucosa confirms GIM and/or atrophic gastritis.

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Gastrointest Endosc
American Society for Gastrointestinal Endoscopy standards for fellowship training in peroral endoscopic myotomy.

This consensus effort provides evidence-based minimum standards for POEM training, applicable to both GI and surgical trainees. These recommendations are intended to guide the structure of training programs, ensure safe dissemination of POEM, and support the evolution of competency-based education in third-space endoscopy.

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Meta-analysis

meta-analyses and systematic reviews

Am J Gastroenterol
Adjunctive Use of p53 Immunohistochemistry for Risk Stratification in Barrett's Esophagus: A Systematic Review and Meta-Analysis.

While aberrant p53 expression has been associated with an increased risk of progression to advanced neoplasia in BE patients undergoing surveillance, the diagnostic characteristics are suboptimal precluding uniform clinical adoption. Prospective studies with standardized grading protocols are needed to determine whether p53-guided surveillance strategies can meaningfully improve patient outcomes.

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Clin Gastroenterol Hepatol
Systematic review of participation, positivity and yield over time in fecal immunochemical test-based organized colorectal cancer screening programs.

Organized FIT-based CRC screening programs achieve consistent participation in nearly half of persons and no participation in approximately one third. FIT-positivity and yields for CRC, AA, and adenoma are highest in the first round and may stabilize at clinically relevant steady states at the third to fourth rounds.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther
Clinical Trial: Early Nivolumab Addition to Regorafenib in Patients With Hepatocellular Carcinoma in Second-Line (The GOING Trial).

The add-on strategy of regorafenib plus nivolumab in second-line had manageable safety and significant clinical activity with a noteworthy median overall survival of 20 months. Among those progressing on sorafenib, 45% were alive at 3 years. These findings support further evaluation with mechanism-guided trials after progression on immunotherapy.

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Differential visceral blood flow in the hyperdynamic circulation of patients with liver cirrhosis.

Rather than a generalised systemic hyperdynamic circulation, liver disease is associated with dysregulated splanchnic vasodilatation and portosystemic shunting that, while inducing a high cardiac output, causes compensatory extra-splanchnic vasoconstriction - the 'splanchnic steal' phenomenon. These circulatory disturbances may underlie many of the manifestations of advanced liver disease.

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Novel Symptom Subgroups in Patients With Irritable Bowel Syndrome Are Associated With Healthcare Utilisation in Secondary and Tertiary Care.

In patients with IBS in secondary and tertiary care, the LCA model identified groups of individuals with more severe symptoms and greater impairments in quality of life at baseline and significantly higher rates of healthcare utilisation during longitudinal follow-up.

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Am J Gastroenterol
Colorectal neoplasia rates in Li Fraumeni Syndrome.

LFS patients have comparable ADR and higher SDR to average risk adults despite earlier, more frequent surveillance, irrespective of TP53 PGV subtype. Our data support current recommendations for earlier and more frequent colonoscopy surveillance than average-risk guidelines, across LFS phenotypes.

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Differences in Outcomes following Ileocecal Resection in Older Adults with Crohn's Disease in the Biologic Era.

Older adults had lower symptom-based clinical recurrence rates but higher mortality.

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High detection rates and associated factors of colorectal serrated lesions: a multicenter prospective study in the Asia-Pacific.

This multicenter study demonstrates that detection rates and estimated prevalence of SLs are higher than previously reported in the Asia-Pacific and highlights the impact of institutional differences, challenging the notion of their low regional prevalence.

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Histogenetic Classification Predicts Outcomes in 130 Adults with Chronic Intestinal Pseudo-Obstruction.

Integrated genetic and histological evaluation informed etiological classification in adults with CIPO and may aid clinical decision-making.

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Clin Gastroenterol Hepatol
Antiviral therapy reduces HCC and cirrhosis risk in Chinese chronic hepatitis B patients with mildly elevated ALT.

NA therapy reduced the risk of HCC and cirrhosis in non-cirrhotic CHB patients with mildly elevated ALT levels (1-2×ULN). These findings support the expansion of antiviral treatment criteria for the early treatment of these patients.

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Immediate vs. On-demand Endoscopic Necrosectomy in Infected Walled-off Pancreatic Necrosis: A Randomized Controlled Trial.

In patients with infected walled-off pancreatic necrosis, immediate necrosectomy was not superior to on-demand necrosectomy. However, the on-demand strategy was associated with fewer necrosectomy sessions, and fewer adverse events. number NCT05530772.

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Pre-diagnostic Changes in the Metabolome of Inflammatory Bowel Disease.

Results A total of 1,206 metabolites were significantly altered prior to IBD diagnosis (p 1000 metabolites up to 14 years prior to diagnosis of IBD, most pronounced in individuals with later CD. Our findings suggest a long pre-clinical phase of IBD, where mucosal breakdown contributes to production of inflammation-modulating lipids.

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Uncomplicated Choledocholithiasis in Elderly Patients: A Target Trial Emulation Comparing Observation and ERCP (CHOIcE).

In elderly patients with uncomplicated choledocholithiasis, early ERCP was not associated with improved outcomes. Findings support a selective, 'as-needed' approach to ERCP in this population.

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Upadacitinib Maintenance Therapy in Pediatric Ulcerative Colitis: 52-week Multicenter Study from the Porto Group of ESPGHAN.

Upadacitinib is an effective induction and maintenance therapy for refractory pediatric UC and IBD-U. Effectiveness should be weighed against the potential risks of AEs.

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Gastroenterology
Immediate or On-Demand Endoscopic Necrosectomy for Necrotizing Pancreatitis: A Randomized Controlled Trial (WONDER-01).

Compared with the step-up approach, immediate DEN following EUS-guided drainage of necrotizing pancreatitis reduced time to clinical success without increasing adverse outcomes but required more DEN procedures (ClinicalTrials.gov, Number NCT05451901).

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Incidence of Cancer in Patients With Familial Adenomatous Polyposis in the Netherlands: A Nationwide Cohort Study.

Despite developments in preventive treatments, individuals with FAP remain at increased risk for multiple cancers, underscoring the need for improved screening and surveillance strategies.

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The MetALD-ALD Prediction Index: A Phosphatidylethanol-Driven Biomarker Panel for Identifying Individuals With Steatotic Liver Disease and Excessive Alcohol Use.

MAPI is a novel, accurate, and scalable biomarker panel for detecting MetALD-ALD. MAPI may guide confirmatory PEth testing in clinical practice and be leveraged in observational cohort studies lacking PEth measurements, as well as in clinical trials.

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Gastrointest Endosc
Ability of computed tomography and endoscopic ultrasound to predict pTNM of resected ampullary adenocarcinomas (AC): an analysis of the French Fédération Française de Cancérologie Digestive AC prospective cohort study.

Although the overall performance of both modalities was low, we found that both EUS and CT had good NPV for the prediction of pN0 and EUS had a good NPV for predicting pT1.

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Durable Partial Reversal of Roux-en-Y Gastric Bypass Using the Parallel-Lumen Apposing Metal Stent Septotomy Technique: A Multicenter Feasibility Study.

Parallel-LAMS septotomy provides a safe and effective endoscopic approach to achieve a durable GG anastomosis, thereby partially reversing RYGB without reliance on in-dwelling stents.

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Lyon ESD Dissection score: A pre-procedure prediction model for operating time in colorectal endoscopic submucosal dissection.

This validated pre-procedure scoring system accurately predicts colorectal ESD duration, especially for longer procedures. It may facilitate scheduling, optimize resource use, and improve workflow in endoscopy units.

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Role of Prophylactic Antibiotics in Patients Undergoing EUS-Directed Transgastric Interventions (EDGI) in Roux-en-Y Gastric Bypass and EUS-Gastroenterostomy (EUS-GE).

Prophylactic antibiotics for EDGI and EUS-GE did not significantly improve infection-related outcomes.

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Gut
E-cadherin loss in Cd44-positive gastric cells initiates diffuse gastric cancer in a murine model.

Background inactivation.

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Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation.

OA promotes endothelial barrier dysfunction and exacerbates HTG-AP-associated ALI via the Piezo1/NR4A1/CPT1A axis by impairing FAO, offering a novel mechanistic insight and identifying potential therapeutic targets for HTG-AP-associated ALI.

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Parental obesity and risk of metabolic dysfunction associated steatotic liver disease in adult offspring: UK birth cohort study.

Excess parental adiposity pre-pregnancy was associated with a higher odds of offspring MASLD, mediated by cumulative excess childhood BMI, highlighting the potential of life course interventions to reduce the risk of MASLD in future generations.

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Hepatology
Deep learning-assisted tumor radiomic dynamics on MRI predict pathological complete response in HCC undergoing immune-based therapy followed by hepatectomy.

Dynamic radiomic changes effectively predict pCR in uHCC after conversion therapy. Combining delta radiomics with AFP response significantly improves predictive performance, offering a non-invasive method for assessing pCR and potentially guiding personalized treatment decisions.

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Dietary anthocyanins alleviates age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota-bile acid-hepatic FXR signaling.

Cy-3-G alleviates age-dependent hepatic steatosis by selectively promoting L. reuteri expansion and reshaping bile acid composition to activate hepatic FXR signaling. These findings identify a gut microbiota-mediated mechanism by which a dietary anthocyanin mitigates age-related MASLD.

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Long-term outcomes of atezolizumab-bevacizumab in unresectable hepatocellular carcinoma: A real-world study.

Our data confirmed sustained effectiveness of AB without new safety concerns. Surgical/locoregional treatments after the start of AB and liver decompensation were common, highlighting the need for a multidisciplinary and integrated approach in advanced HCC.

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Myeloid KIF13B suppresses the STT3A/CTSD/THBS1 Axis to prevent MASH.

Collectively, our study establishes a novel regulatory axis, ZNF384/KIF13B/STT3A/CTSD/THBS1, essential for macrophage-hepatocyte crosstalk during MASLD progression and providing potential therapeutic targets for the treatment of MASLD.

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Real-world impact of AUD pharmacotherapy on healthcare utilization, cost, and cost-effectiveness in the U.S.

AUD pharmacotherapy is significantly associated with lower alcohol-associated healthcare utilization, particularly inpatient care, and medical charges in real-world settings, with the largest economic benefits observed in patients without advanced liver disease. These findings support broader implementation of pharmacologic treatment for AUD including in patients with ALD and underscore the importance of early intervention to maximize cost-effectiveness.

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The rise of transplant oncology in primary liver cancer and metastatic disease.

Transplant oncology reshapes the therapeutic landscape of liver malignancies, with growing evidence supporting liver transplantation in carefully selected patients beyond traditional indications. Optimized downstaging, innovative donor strategies, and tailored immunosuppression are pivotal for safe expansion. Continued collaboration between the transplant and oncology disciplines, along with prospective trials, is essential to further define standardized protocols and solidify transplantation as a cornerstone of multidisciplinary cancer care.

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J Hepatol
Development and validation of the A-TANGO organ failure score for acute-on-chronic liver failure in global cohorts.

The A-TANGO OF score is a more accurate, reproducible, and comprehensive tool for diagnosing ACLF with well-maintained prognostic ability, validated in large global cohorts. The A-TANGO OF score offers a robust tool for clinical trials enabling more reliable diagnosis, reducing the required sample size and providing readily assessable clinical endpoints, such as ACLF resolution, to define treatment responses effectively. Impact and Implications The A-TANGO organ failure (OF) score provides a scientifically justified advancement in ACLF research by refining organ-specific dysfunction thresholds and introducing a new grade 4, thereby addressing limitations in current EASL-CLIF criteria and improving identification of high-risk patients. These findings are important for clinicians, researchers, and healthcare systems globally, as they increase detection of organ failure, enhance risk stratification, and allow more accurate prediction of short-term mortality in hospitalized patients with cirrhosis. The A-TANGO OF score and its associated prognostic scores (ACLF-WBC and ACLF-CRP) can be applied in clinical practice to guide treatment decisions, and serve as reliable, measurable endpoints in clinical trials evaluating emerging therapies. Although limitations such as missing data, cohort-specific recruitment differences, and historical classification criteria exist, the consistent and robust performance of the A-TANGO scores across large, multinational cohorts highlights their potential applicability and utility on a global scale.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol
Blue Notes.

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Gastroenterology
ANORECTAL DISORDERS.

Biofeedback therapy is efficacious in DD. Rectal sensory disorders are defined by both anorectal symptoms and increased (hyposensitivity) or decreased (hypersensitivity) sensory thresholds during rectal balloon distension, and sensory biofeedback is useful.

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BOWEL DISORDERS.

Each disorder is defined, followed by sections on epidemiology, rationale for changes from prior criteria, clinical evaluation, pathophysiology and treatment. It is in hope that the Rome V BD Committee will assist clinicians and researchers in improving diagnosis, patient care and scientific endeavors of these common and burdensome disorders.

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Development of the Rome V Diagnostic Questionnaires.

The results indicate that the new questionnaires generally identify DGBI to a similar degree and with the same demographic patterns as the prior Rome IV versions. The Rome V Questionnaire Committee concluded that these new diagnostic questionnaire versions are well suited for epidemiologic and clinical research of DGBI in the Rome V era for both adult and pediatric populations.

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Fundamentals of Neurogastroenterology: Physiological Aspects and Clinical Implications.

In this article, normal physiology and pathophysiology of GI function, and processes underlying symptom generation are reviewed. This article provides a thorough appraisal of symptom profiles, pathogenesis and functional tests of the wide array of DGBI.

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Gallbladder and Sphincter of Oddi Disorders.

With growing recognition that these disorders have traditionally been over-diagnosed and their treatments - which are risky - have been overused, the approach to cholecystectomy and endoscopic retrograde cholangiopancreatography has become progressively more restrictive. This trend continues in Rome V, although predictors of response to therapy, especially for biliary and pancreatic SOD, are desperately needed.

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Gastroduodenal Disorders.

Symptoms that can be attributed to the gastroduodenal area are classified into five categories: (1) Functional Dyspepsia, with two subcategories that can overlap: Postprandial Distress Syndrome, with meal-induced symptoms of postprandial fullness or early satiation and Epigastric Pain Syndrome, with epigastric pain or burning that does not occur exclusively postprandially; (2) Nausea and Vomiting Disorders, which include three subcategories: chronic nausea and vomiting syndrome; cyclic vomiting syndrome; and cannabinoid hyperemesis syndrome; (3) Excessive Belching Disorders, defined as audible escapes of air from the esophagus or the stomach and classified into 2 subcategories depending on the origin of the refluxed gas: gastric or supragastric belching; (4) Inability to Belch Syndrome, a new category defined by the self-reported inability to belch; and (5) rumination syndrome, defined by the repetitive, effortless regurgitation of recently ingested food into the mouth followed by the reswallowing or expulsion of the food bolus.

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Lower and Biliary Disorders of Gut-Brain Interaction: Child/Adolescent.

Rome V also acknowledges that DGBIs may coexist with other conditions producing gastrointestinal symptoms. These updates are intended to support a more consistent diagnostic framework and guide appropriate management strategies for children and adolescents.

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Rome V Pediatric Upper Gastrointestinal Disorders of Gut-Brain Interaction.

This harmony between symptoms and testing results in more precision in therapeutic approaches that are critically multidisciplinary. The ability to assign new, positive diagnoses across the upper gastrointestinal tract offers new opportunities for pediatric-focused therapeutic trials.

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J Hepatol
Cardiovascular Risk in MASLD: What Multiple Lines of Evidence Reveal.

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Updates in clinical medicine: MASLD in children and adolescents.

We also outline a practical approach to the management of MASLD in children, integrating newly developed non-invasive tests. Lastly, we provide key research questions to be studied in the coming years.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
Calendar of Courses, Symposiums and Conferences.

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Evaluating the Use of Sex in Gastroenterology Algorithms: A FAIRS Framework Analysis.

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Letter to the Editor.

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Letter to the Editor.

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Letter to the Editor.

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Mycobacterium fortuitum: A Liver Mass in Luck.

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Response to Lewis et al.

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Response to Moutsoglou and Friedrichs.

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Clin Gastroenterol Hepatol
Automated phenotyping with AI predicts future advanced neoplasia risk in colitis-associated low-grade dysplasia.

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Muscle Retracting Sign in Colorectal Macronodular Lesions: Prevalence, ESD Outcomes, and Submucosal Cancer Predictors.

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Endoscopy
A mirage under the water: underwater detection of an obscure anastomotic leakage.

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A simple device for assisting capsule endoscopy in passing through complex duodenal stenosis.

Pubmed   Journal   ReadQx   PMC

Artificial intelligence-supported polyp detection (CADe) at colonoscopy reduces the detection of high grade dysplasia and invasive cancer.

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Building a durable "rural-to-center" endoscopy artificial intelligence system: practical enhancements for scale.

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Direct cholangioscopic visualization during placement of overlapping stents in malignant duodenal horizontal segment obstruction.

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Endoscopy E-Videos - recently published.

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Enhanced endoscopic transillumination enables precise tumor delineation in laparoscopic-endoscopic cooperative surgery for duodenal neuroendocrine tumor.

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From chronology to morphology: toward objective image-guided assessment of endoscopic ultrasound-guided drainage for walled-off necrosis.

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Gel-immersion peroral cholangioscopy-guided biopsy can maintain a clear endoscopic view during bleeding.

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Gel-immersion-assisted laser ablation of a self-expandable metal stent using a novel 3-o'clock-channel cholangioscope.

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Hybrid endoscopic rescue following endoscopic ultrasound-guided choledochoduodenostomy.

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Multi-traction multi-tunneling techniques combined with novel enhanced imaging to facilitate endoscopic submucosal dissection of large rectal lesions.

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Outpatient overstitch repair of perforation following endoscopic submucosal dissection: a novel, cost-effective approach.

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Per-oral endoscopic tunneling transgastric drainage of an acute pancreatic necrotic collection.

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Peroral cholangioscopic diagnosis of refractory hemobilia caused by pancreatic arteriovenous malformation: a case report.

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Recovery of a migrated stent during endoscopic ultrasound-guided pancreatic pseudocyst drainage using a lithotripsy basket.

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Single-arm robot-assisted endoscopic mucosal resection for oxyntic gland adenoma in the gastric fundus.

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Successful complete closure of anastomotic leak in ileal pouch anal anastomosis with endoscopic helix tacking device.

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Variceal transection with endoscopic submucosal dissection as a rescue therapy for esophageal varices with severe scarring.

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Gastroenterology
Can Colonoscopy Still Be Promoted as the Best Choice for Colorectal Cancer Screening?

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The best screening test is the one that gets followed up on.

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Visualizing Science in Gastroenterology: The Role of Infographics and Graphical Abstracts in Education, Communication, and Research Dissemination.

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Gastrointest Endosc
A management innovation of gastric perforation from percutaneous endoscopic gastrostomy tube placement.

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Cholangioscopic Diagnosis of Intrahepatic Fascioliasis Presenting as Eosinophilic Ascites in a Non-Endemic Area.

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Endoscopic ultrasound assisted identification of ectopic papilla of Vater below the pylorus.

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Peroral pancreatoscopy-guided chemical ablation for a case of intraductal papillary mucinous neoplasm (with video).

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Successful Endoscopic Transpapillary Gallbladder Drainage With a Novel Catheter in a Patient with Malignant Biliary Stricture.

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When Pancreatitis Shows Its Face: A Rare Case of Pancreatic Panniculitis.

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Hepatology
Stains in primary biliary cholangitis: Untangling promise from bias.

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J Hepatol
MASLD and breast cancer risk: The role of hepatocyte-derived exosomes.

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Neoantigen-based vaccination unlocks precision immunotherapy in fibrolamellar carcinoma.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Letter: Association of Diabetes Mellitus With Post-TIPS Hepatic Encephalopathy in a Predominantly Viral Cirrhosis Cohort-Authors' Reply.

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Letter: Association of Diabetes Mellitus With Post-TIPS Hepatic Encephalopathy in a Predominantly Viral Cirrhosis Cohort.

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Letter: Statins for Cirrhosis: Are We Ready to Move From Cardiovascular Prophylaxis to Portal Pressure Management?

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Letter: Statins for Cirrhosis: Are we Ready to Move From Cardiovascular Prophylaxis to Portal Pressure Management? Authors' Reply.

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Gastroenterology
From Narrow Convolutional Neural Networks to Endoscopic Foundation Models: Implications for Sessile Serrated Lesion Detection.

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GastroNet-5M: Closing the Gaps for Global Clinical Impact.

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Glycemically Defined New-Onset Diabetes: A Window for Early Detection or a Marker of Aggressive Biology in Pancreatic Cancer?

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Pancreatic cancer risk in glycemically defined new-onset diabetes.

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Rethinking Infliximab Dosing in Acute Severe Ulcerative Colitis with Model-Informed Precision Dosing.

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Temporal Clustering of Pancreatic Cancer After GNOD: A Call to Rethink Early Detection Strategy.

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Time-Anchored Risk After Glycemically Defined New-Onset Diabetes and Its Implications for Pancreatic Cancer Detection.

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Gut
Clarifying decision rules and implementation boundaries for a two-step Fibrosis-4-vibration-controlled transient elastography pathway in type 2 diabetes MASLD.

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Metabolic determinants of hepatocellular carcinoma after SVR: persisting uncertainties.

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J Hepatol
Conversion surgery as a missing outcome in first-line immunotherapy trials for hepatocellular carcinoma: Conversion surgery in HCC immunotherapy.

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Differences in Immunosuppressive Strategies for Primary Sclerosing Cholangitis After Liver Transplantation.

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Early portopulmonary hypertension: a signal of increased mortality risk in cirrhosis.

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Ketogenic diets in MASLD: methodological limitations and the confounding role of protein intake.

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